In findings that mirror the human literature, an alcohol preferring (P) mouse strain had a reduced P300 amplitude compared to a non-alcohol preferring (NP) mouse strain [96]. A follow-up study further indicated that reductions in evoked delta event-related oscillations and decreases in delta and theta phase synchrony contributed to this P300 amplitude reduction [97]. Additional studies are needed to identify the genetic differences between these selectively bred mouse models that are associated with these neurophysiological endophenotypes.
