Rat models suggest that P animals have lower LR compared to NP animals; for example, in a conditioned place aversion test, P rats avoided an alcohol-paired location less than NP rats [98], suggesting that P rats are less sensitive to the aversive effects of alcohol. here have also been attempts to translate the body sway dimension of LR into rodent models; however, the lack of concordance between the human phenotype and rodent models makes development of novel behavioral assays an important area for continued refinement [for a review see 99]. A series of eleven rodent behavioral assays broadly indexing body sway were tested across eight inbred mouse strains. Interestingly, there was little genetic correlation across the behavioral assays, suggesting that unique sets of genes contribute to foot slippage and wobbly gait, for example [100]. The degree to which unique sets of genes contribute to the component processes of human body sway is unknown. Despite these challenges to phenotype consilience across species, convergent evidence from cross-species (humans, mice, and fruit flies) analyses of locomotor responses to ethanol implicated the glypican gene GPC5 on chromosome 13 [101].
