The UK Brain Expression Consortium Braineac data set contains data from 10 brain regions obtained from 134 control individuals: frontal cortex, temporal cortex, occipital cortex, hippocampus, thalamus, putamen, substantia nigra, medulla, cerebellum, and white matter, together with the mean expression across all 10 regions.6,8,14 Gene expression was quantified using Affymetrix Exon 1.0 ST arrays (Thermo Fisher Scientific), and the genotyping was performed using Illumina Infinium Human Omni1-Quad BeadChip microarrays (Illumina Inc), then imputed to the European panel of the phase 1 1000 Genomes Project.15,16 The genotyped and imputed data were restricted to approximately 5.88 million SNVs with minor allele frequency of 0.05 or more and imputation r2 > 0.5. For each gene of interest, all SNV associations within 1 Mb upstream and downstream of the gene were collected.17
