The consistency of gene coexpression network architecture motivated us to rank genes according to their average module membership across brain regions (Supplementary Table 9 online). Genes with the highest average module membership best conformed to the characteristic expression pattern of their respective module in multiple human brain regions. This analysis can therefore be used to identify genes with a strong likelihood of participation in the specific functions represented by each module. For example, the ten genes with the highest average membership for M9, which was highly enriched with markers of oligodendrocytes (Table 1), were PLLP, MAL, HSPA2, TF, GPR37, CNP, ENPP2, FA2H, C11orf9 and ENPP2 (Supplementary Table 9). These data predict that C11orf9, which encodes a protein of unknown function, is important for oligodendroglial function in the human brain. The ten genes with the highest average membership for M15, which was highly enriched with markers of astrocytes (Table 1), were AHCYL1, AHCYL1, NTRK2, SOX9, PDLIM5, PPAP2B, PLSCR4, TP53BP2, METTL7A and NTRK2 (Supplementary Table 9). Notably, these genes showed higher average membership than many genes that are considered to be canonical
