To further explore the relationships between cortical gene coexpression modules, we directly compared module eigengene networks for conserved modules that were identified in both CTX and CTX_95 (Supplementary Fig. 7 online; comparisons between brain regions are presented in Supplementary Fig. 6). The overall preservation of the two cortical networks was quite high (mean preservation = 0.87, s.e.m. = 0.014; Supplementary Fig. 7). Hierarchical clustering of conserved modules identified three main clusters of meta-modules: one with characteristics of glia, one with properties related to the synapse/cell membrane and one with characteristics of neurons (Supplementary Fig. 7). These results indicate that the higher-order organization of gene coexpression networks in the human brain is reproducible and reflects functional inter-relationships between modules.
