enriched for astrocyte markers (M15C, r = 0.60, P = 8.4 × 10−4; Supplementary Fig. 6). In both CTX and CB, modules related to synaptic function (M10 and M14) were significantly correlated (r = 0.59, P = 1.3 × 10−7 (CTX) and r = 0.58, P = 3.1 × 10−3 (CB); Supplementary Fig. 6), as were modules related to synaptic and mitochondrial function (M10 and M7) (r = 0.56, P = 8.9 × 10−7 (CTX) and r = 0.62, P = 1.1 × 10−3 (CB); Supplementary Fig. 6). In all networks, modules enriched with genes that are preferentially expressed in neurons (M16) and astrocytes (M15) were significantly anti-correlated (r = −0.58, P = 2.6 × 10−7 (CTX); r = −0.51, P = 6.0 × 10−4 (CTX_95); r = −0.71, P = 2.9 × 10−5 (CN); r = −0.52, P = 9.7 × 10−3 (CB); Supplementary Fig. 6).
