The variant rs13273442 is associated with nicotine dependence in the European Ancestry group (Table 2). The point estimates of the odds ratios display a consistent direction of effect for the A allele across all three studies, resulting in a highly significant association (p = 5.8 × 104) between the variant and nicotine dependence after adjusting for comorbid alcohol, marijuana, and cocaine dependence. The meta-analyzed European ancestry samples result in an estimated OR=0.75 (95% CI=(0.64–0.88)).
