In the African American sample (Table 2), the results for rs13273442 are consistent with those found in the European ancestry sample. After including all four substance dependence diagnoses in the model, the meta-analysis results for nicotine dependence indicate a protective effect for the A allele seen in the point estimates in each of the sub-studies. Meta-analyzing the 3 African American samples results in a nominally significant association (p=0.05) and an odds ratio estimate (OR=0.80, 95% CI (0.64–1.00)) very similar to the one estimated from the European samples.
