Conversely, heritability of PD—more prevalent in non-Hispanic WAs44—showed enrichment among DEGs with an increase in EA proportion. Ancestral DEGs enriched heritability for several immune disorders and traits but not specifically with either ancestry across the brain. It is noteworthy that the DEGs are not linked with heritability of psychiatric disorders and related behavioral traits, perhaps consistent with genes associated with these traits being especially enriched in neurons, which were again conspicuously lacking in DEGs based on ancestry.
