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Chunk #22 — Results

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The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies.
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Finally, we examined the relationship of current depression to both SLC6A4 methylation and gene expression. No significant relationships using logistic regression or categorical cutoffs (>4 current symptoms denoting current MD) were noted, though we note that only 16 subjects met 5 or more criteria for MD at the time of the blood draw that led to the establishment of the lymphoblast lines.