(2 upregulated and 5 downregulated) and nine paired mRNAs (8 upregulated and 1 downregulated) could regulate three pathways (Synaptogenesis Signaling, CREB Signaling in Neurons, and Neuroinflammatory Signaling) (Fig. 4c). Within the HIP, 21 miRNAs (13 upregulated and 8 downregulated) and 15 paired mRNAs (9 upregulated and 6 downregulated) could regulate four pathways (G-Protein Coupled Receptor Signaling, CREB Signaling in Neurons, Synaptogenesis Signaling, and Axonal Guidance Signaling) (Fig. 4d). Moreover, within the NAc, two upregulated miRNAs and two paired downregulated mRNAs could regulate one pathway (i.e., CREB Signaling in Neurons) (Fig. 5a). Within the PFC, 19 miRNAs (14 upregulated and 5 downregulated) and 22 paired mRNAs (5 upregulated and 17 downregulated) could regulate four pathways (IL-8 Signaling, Axonal Guidance Signaling, CREB Signaling in Neurons, and G-Protein Coupled Receptor Signaling) (Fig. 5b). Within the PUT, four miRNAs (3 upregulated and 1 downregulated) and four paired mRNAs (2 upregulated and 2 downregulated) could regulate two pathways (Sirtuin Signaling and IL-8 Signaling) (Fig. 5c). Within the VTA, nine miRNAs (2 upregulated and 7 downregulated) and 10 mRNAs (9 upregulated and 1 downregulated) could regulate five pathways (Opioid Signaling, CREB signaling in Neurons, IL-8 Signaling, NRF2-mediated Oxidative Stress Response, and Gap Junction Signaling) (Fig. 5d).
