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Chunk #18 — Results — Association analyses among at-risk US young adults

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Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients.
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found in the Caucasian subgroup (N = 66): TaqIB 3 genotypes: χ2 = 15.415, df = 2, p = 0.0004; B1+ vs B1- categories: χ2 = 14.139, df = 1, p = 0.0002, OR = 10.1 (2.7-37.6). TaqIA 3 genotypes: χ2 = 11.253, df = 2, p = 0.004; A1+ vs A1- categories: χ2 = 11.215, df = 1, p = 0.001, OR = 7.7 (2.13-27.99). With gender and severity of abuse accounted for in the model, the effect of DRD2 SNPs was still significant (Table 4). Similar results appeared in the Caucasian subgroup (Table 4). For the APD traits, only the DRD2 TaqID SNP showed a nominally significant association (p = 0.046) which did not remain significant after correcting for multiple comparisons.