This study has to be viewed in light of its strengths and limitations. Data from separate cohorts with different characteristics were used, which results in a large sample size and high generalizability. It also induces measure heterogeneity, which on the one hand may have limited the power to detect effects in the meta‐analyses and on the other hand further substantiates the robustness of findings. This study included a range of risky behavior and self‐control phenotypes, potentially expanding the findings. Furthermore, previous research also indicates that CADM2 may play a role in phenotypically heterogeneous risk‐taking behaviors and personality. 1 , 23 Future studies might further explore the role of CADM2 in other potentially related phenotypes, such as (a lack of) physical activity, eating patterns or overweight, gambling, and reckless driving 2 and should investigate if these results generalize to populations with different age ranges or different genetic ancestry.
