We tested for functional genomic enrichment in our BD GWAS using partitioned LD-score regression and a range of functional annotations across tissues 46 (Supplementary Note, Supplementary Table 14). SNP-based BD heritability was most enriched in open chromatin annotations in the central nervous system (proportion SNPs = 0.14, proportion h2snp = 0.60, enrichment =3.8, p = 3 × 10−14). We also used DEPICT 47 to test for expression of BD-associated genes across tissues, and found significant enrichment of central nervous system (p < 1.4×10−3, FDR < 0.01) and neurosecretory system (p = 2.0×10−6, FDR < 0.01) genes (Supplementary Table 15).
