104 permutations over the 3 performed genetic models and all SNPs tested per study. Empirical and nominal p-values for all reported associations did not deviate from each other. Moreover, sample demographic statistics and post-hoc tests on age, gender and German origin, life events, recurrence of MD, age at onset, number of previous depressive episodes, first degree family history of MD and life time attempted suicide status were performed by logistic regression analysis and ANCOVA. P-values including these covariates did not differ from those of the Chi square test statistics for all reported associations. Thus, none of these additional covariates showed a significant effect on the reported associations. In the RADIANT study from the UK, sex was coded as a factorial covariate for the analysis presented in the main text. The validity of the p-values and the distribution of the estimates were verified using Monte-Carlo (permutation and bootstrap) methods. Below we give the odds ratios (OR) without sex as a factorial covariate and the ORs in a gender stratified analysis: OR of all RADIANT cases and RADIANT plus WTCCC2 controls, sex not included as covariate: 1.082 (95% C.I. 0.951; 1.231), n = 1636 cases and 7261 controls with a p =
