(sign test, P = 0.006) although no SNP neared genome-wide significance (minimum P = 4.8×10−6 at rs1969253, chr3: 185 359 206). For male cases and controls, the sign test was not significant (P = 0.17), and no SNP was genome-wide significant (minimum P = 3.8×10−7 at rs2498828, chr14:91 491 028). For recurrent MDD, there was greater evidence of consistency of effects between the discovery and replication samples (sign test, P = 0.006), and the minimum P-value was 1.0×10−6 at rs2668193 (chr3:185 419 374).
