Heterogeneity is a major concern for any genetic association studies employing a sample comprised of mixed ethnicities. Thus, our data were analyzed separately for each ethnic-specific sample, while the results from the pooled sample were also computed to capitalize on improved power due to increased sample size (assuming a lack of heterogeneity across samples). As shown in Table 2, we found that all five SNPs examined in this study showed significant association with at least one ND measure in one of the three samples. However, only the association of SNP rs4758416 with SQ and HSI remained significant after correction for multiple testing in the pooled sample.
