We employed the FBAT program to analyze the association between haplotypes and ND measures. We scanned all possible haplotypes consisting of three consecutive SNPs, and found three haplotypes that were significantly associated with ND after Bonferroni correction (Table 3). The first two haplotypes, formed by rs4758416-rs10839562-rs1079199, were C-C-T and G-C-T. The haplotype C-C-T showed positive associations with all three ND measures in the AA and pooled samples. However, after correction for multiple testing, only the association with FTND remained significant in the AA (Z = 2.50; P = 0.012; 91 informative families) and pooled (Z = 2.63; P = 0.008, 109 informative families) samples. On the other hand, the G-C-T haplotype showed significant inverse association with all three ND measures for the three samples. After correction for multiple testing, we found that this haplotype remained significant with at least one ND measure in each of the three samples. For example, this haplotype was significantly associated with SQ in the AA sample under both the additive (Z = −2.67; P = 0.008, 128 informative families) and dominant models (Z = −2.75;
