The top significant finding involves three genome-wide significant SNPs (rs7031417: q=0.01, p=1.4E-08; rs17053864: q=0.05, p= 1.5E-07; rs7019589: q=0.06, p=2.3E-07) at pseudogene LOC100129340 (mitofusin-1-like) associated with mean adolescent alcohol consumption. These SNPs show moderately low MAF (~0.09) with minimal MAF differences across the three samples (Table 2). Study specific results show that this meta-analysis association was not driven by a single sample, with GSMS and CHDS exhibiting comparably low p-values (Table 2). Examination of the regional plot for the locus shows a robustly associated haplotype spanning ~100kb with >10 spatially clustered SNPs showing nominal association (Supplementary Material 3A). Notably, one of the genome-wide significant hits is located in the transcribed exon 4.
