The second genome-wide significant association, also to mean consumption, is a locus in GABA transporter SLC6A1 (solute carrier family 6 (neurotransmitter transporter, GABA), member 1). In addition to the genome-wide hit in this gene (rs11710497: q=0.05, p=1.2E-07), a second SNP met our suggestive criteria (rs6778281: q=0.15, p=7.1E-07). Again, MAFs were moderately low (~0.10) and highly comparable across individual samples. Also, significance was not driven by a single study, with comparably low p-values for GSMS and VTSABD (Table 2). Inspection of the regional plot indicates a fairly small LD block overlaying exonic regions of SLC6A1. Further, this small linkage disequilibrium (LD) block is highly enriched for strong associations including several nominally associated coding SNPs (p<0.001) (Supplementary Material 3B).
