Top findings for the developmental consumption trajectory included a cluster of correlated SNPs about 150kb upstream of ADRA2A (adrenoceptor alpha 2A), with rs12257178 exhibiting the strongest association (q=0.14, p=4.8E-07). MAFs were high (~0.4) and homogenous across studies. Association strength was primarily driven by GSMS and CHDS samples (Table 2). While it is questionable whether this putative susceptibility locus is in LD with ADRA2A, the regional plot does show a correlated SNP located ~80kb upstream of the gene (Supplementary Material 3C). Also, further inspection of the regional plot indicates an unusually wide area of moderately enriched association surrounding the suggestive locus, spanning ~500kb and encompassing ADRA2A.Thus, it is possible that this association may tag cis regulatory elements or genic variants for ADRA2A.
