Other top hits included a pair of SNPs in high LD (R2>0.9) within ZNF578 (rs1984450 and rs7253326: q=0.14; p≈2.7E-07) associated with the trajectory outcome, and an interesting spatial pattern of SNPS associated with mean consumption surrounding an intronic SNP in MIPOL1 (rs4898641: q=0.19, p=1.1E-06). The ZNF578 finding exhibits almost exactly the same level of association across studies (p≈3.0E-03) and moderately low MAF (~0.10). Correlated signals overlapped ZNF578 and the adjacent ZNF808 and ZNF701 genes, and tag two nominally significant coding SNPs in ZNF578 (Supplementary Material 3D). Next, rs4898641 in MIPOL1 appears to tag a ~200kb haplotype, enriched for association, which closely corresponds to the gene boundaries of MIPOL1 (Supplementary Material 3E). Our final suggestive finding involved a genic locus in IGSF9B centered on rs694424 (q=0.14, p=5.4E-07) (Supplementary Material 3F). This finding is of lower confidence, however, as its association strength is essentially driven by a single sample (VTSABD).
