Results from ConsensusPathDB indicated significant involvement of several intuitive biological pathways (Table 3). As ConsensusPathDB is a meta-database bioinformatic tool, it mines multiple individual databases—in the current analysis significant (q<0.1) pathways were found in Reactome, PharmGKB, Signlink and Wikipathways databases (Kamburov et al., 2011). The top pathways, “neuronal system” (p= 2.5E-07, q=4.5E-04) and the related “transmission across chemical synapses” (p=3.7E-05, q=3.3E-02), indicated an association between genetic variation in neurotransmission and individual differences in mean adolescent alcohol consumption, with disproportionate representation of GABAergic and glutamatergic genes in both of these pathways. Other significant pathways for mean adolescent consumption including “nuclear hormone receptors” (p=2.6E-04, q=9.4E-02), “celecoxib pharmacodynamics” and “adherens junctions interactions” (p=2.1E-04, q=9.4E-02) (Table 3). The three significant pathways for the developmental consumption trajectory indicated more general developmental themes, with specific findings including “developmental biology” (p=7.6E-05, q=8.1E-02), “G protein signaling pathways” (p=1.1E-04, q=8.1E-02) and “axon guidance” (p=1.3E-04, q=8.1E-02).
