paperKB
coga / coga-kb
Help
Sign in

Chunk #53 — Results — Simulation

Source
Dosage transmission disequilibrium test (dTDT) for linkage and association detection.
Embedded
yes

Text

We can further see how the penetrances differ by looking at the slope of the trend in each bin. Apparently as the value of R increases across the bins, the slope of the trend also increases. This is because when R is high (such as 0.9 and 1.0), the same degree of lift in the penetrances will add more power and move/more quickly to its next level compared to the situation when R is low (such as 0.5). From another point of view, we can imagine these slopes as the (first) derivatives of a convex function in terms of R. On this convex curve, as R moves along to its rightmost end (increases), the derivative of the function increases and the function value (power) improves faster.