In conclusion, although our data support the contention that heteromeric GIRK1/GIRK2 channels are the prevalent GIRK channels in the developing and adult hippocampus, subpopulations of GIRK channels with distinct subunit composition and subcellular distribution can be discerned. Moreover, this study reveals striking developmental regulation of both the expression and subcellular distribution of neuronal GIRK channel subunits. Molecular, developmental and subcellular diversity in the neuronal GIRK channel repertoire may afford an opportunity for the selective modulation of distinct subpopulations of GIRK channels, an approach that could prove useful for the treatment of disorders of neuronal excitability including seizures.
