PSD-95, Dlg and ZO-1 (PDZ) interaction motif on the GIRK2c splice isoform and/or GIRK3 (Inanobe et al., 1999; Nehring et al., 2000; Kurachi & Ishii, 2004). At present, the functional significance of GIRK channels within the synaptic specialization is unknown, but they might be activated by GABAB receptors, which are known to be also present at excitatory synapses in CA1 pyramidal cells (Kulik et al., 2006).
