A total of 37 participants, 18 men and 19 women aged 21–27, completed the study. All were healthy, non‐treatment seeking, and at‐risk alcohol‐consuming participants comprising 29 and 4 European and African ancestry respectively, with the remainder being of mixed, other, or unknown ancestry (Laboratory Session; Table 1A). All participants were heavy drinkers (≥7/14 drinks per week or ≥3/4 drinks on one occasion for women and men, respectively 6 ). The study was approved by the Indiana University School of Medicine Institutional Review Board. NIAAA guidelines for administering alcohol in human studies were followed. Participants were interviewed, providing demographic and medical information, a recent 35‐day drinking (timeline follow‐back 40 , 41 ), an evaluation of antecubital vein access and vital signs, a blood sample for liver function testing, and a urine sample for drug use and pregnancy‐testing. As tobacco use is also highly prevalent in heavier drinkers, N = 8 recent smokers were included.
