Two studies with more limited measures of stressors did not find evidence consistent with GxE. There was no evidence for an interaction between 5-HTTLPR genotype and past year SLEs on AD risk in a sample of Caucasian probands from the Collaborative Study on the Genetics of Alcoholism (COGA) (Dick et al., 2007b). In a sample of Mexican-Americans with AUDs, education and marital status did not interact with variation in 5-HTTLPR genotype or in the dopamine receptor D2 gene to predict AUD severity (Du & Wan, 2009). However, there was evidence for an interaction between a polymorphism in the opioid receptor mu1 (OPRM1) and education in relation to AUD severity (Table 3).
