(2008) was mainly due to the presence of the mTeSR1 in medium that helped in maintaining the pluripotent state needed for the unlimited production of motor neurons (Chestkov et al., 2014). That being said, it had been shown that mTeSR1 medium supports stem cell growth by containing agonists of signaling systems, such as GABA receptors and ErbB2, which while less characterized, are thought to play a role in human ESCs maintenance (The International Stem Cell Consortium Initiative Consortium et al., 2010). Nevertheless, many other media, like DMEM/F12 medium with 20 ng/mL β-FGF (Cai et al., 2009), that has been used for maintaining iPSCs, are also capable of avoiding uncontrolled differentiation of those iPSCs.
