Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma.
paper
Cited
Public
- Authors
- Bahmad, Hisham; Hadadeh, Ola; Chamaa, Farah; Cheaito, Katia; Darwish, Batoul; Makkawi, Ahmad-Kareem; Abou-Kheir, Wassim
- Year
- 2017
- Journal
- Frontiers in molecular neuroscience
- PMID
- 28293168
- DOI
- 10.3389/fnmol.2017.00050
- PMCID
- PMC5329035
With the help of several inducing factors, somatic cells can be reprogrammed to become induced pluripotent stem cell (iPSCs) lines. The success is in obtaining iPSCs almost identical to embryonic stem cells (ESCs), therefore various approaches have been tested and ultimately several ones have succeeded. The importance of these cells is in how they serve as models to unveil the molecular pathways and mechanisms underlying several human diseases, and also in its potential roles in the development of regenerative medicine. They further aid in the development of regenerative medicine, autologous cell therapy and drug or toxicity screening. Here, we provide a comprehensive overview of the recent development in the field of iPSCs research, specifically for modeling human neurological and neurodegenerative diseases, and its applications in neurotrauma. These are mainly characterized by progressive functional or structural neuronal loss rendering them extremely challenging to manage. Many of these diseases, including Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) have been explored . The main purpose is to generate patient-specific iPS cell lines from the somatic cells that carry mutations or genetic instabilities for the aim of studying their differentiation potential and behavior. This new technology will pave the way for future development in the field of stem cell research anticipating its use in clinical settings and in regenerative medicine in order to treat various human diseases, including neurological and neurodegenerative diseases.
Schematic diagram showing the methods used to generate induced pluripotent stem cells (iPSCs) from human somatic cells as skin fibroblasts or blood cells. The hiPSCs derived from a patient carrying a certain genetic mutation in a neurodegenerative disease have the capacity to differentiate into different neurons. Those patient-specific hiPSCs and hiPS-derived neurons can be expanded and further differentiated into mature neural subtypes specific to certain neurodegenerative diseases.
LLM interpretation
This is a schematic diagram illustrating the process of generating human induced pluripotent stem cells (hiPSCs) and their subsequent differentiation into neurons. The workflow shows somatic cells (skin fibroblasts or activated lymphocytes) being reprogrammed using OKSM factors via various delivery methods (e.g., retrovirus, mRNA) to form iPS cell colonies. These colonies are then differentiated using small molecules to produce hiPSC-derived neurons.
Schematic diagram demonstrating the different applications of induced pluripotent stem cells (iPSCs) derived from human somatic cells. The patient-specific hiPSCs and hiPS-derived neurons can serve as precursors for transplantation and tissue regeneration therapy. hiPSCs generated are also a copious resource for in vitro and in vivo disease modeling, drug and genetic screening, and regenerative medicine.
LLM interpretation
This is a schematic diagram illustrating the applications of human induced pluripotent stem cells (hiPSCs) derived from patient skin biopsies or blood cells. The workflow shows hiPSC-derived neurons being used for *in vitro* disease modeling to decipher disease mechanisms, as well as for drug and genetic screening via multi-well plates to facilitate drug discovery. Additionally, the diagram depicts the expansion of functional cells of interest for therapy or gene correction, leading to transplantation and tissue regeneration in the patient.
1β20 of 63
Next β
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| AasenT.RayaA.BarreroM. J.GarretaE.ConsiglioA.GonzalezF.. (2008). Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol. 26, 1276β1284. 10.1038/nbt.150318931654 | β | β | β |
| AbdullahA. I.PollockA.SunT. (2012). The Path from Skin to Brain: generation of functional neurons from fibroblasts. Mol. Neurobiol. 45, 586β595. 10.1007/s12035-012-8277-622614130PMC3564239 | β | β | β |
| AbelO.PowellJ. F.AndersenP. M.Al-ChalabiA. (2012). ALSoD: a user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics. Hum. Mutat. 33, 1345β1351. 10.1002/humu.2215722753137 | β | β | β |
| Alzheimer's Association (2010). 2010 Alzheimer's disease facts and figures. Alzheimer's Dementia. 6, 158β194. 10.1016/j.jalz.2010.01.00920298981 | β | β | β |
| BarryF. P.MurphyJ. M. (2004). Mesenchymal stem cells: clinical applications and biological characterization. Int. J. Biochem. Cell. Biol. 36, 568β584. 10.1016/j.biocel.2003.11.00115010324 | β | β | β |
| BregmanB. S.McAteeM.DaiH. N.KuhnP. L. (1997). Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp. Neurol. 148, 475β494. 10.1006/exnr.1997.67059417827 | β | β | β |
| ByersB.LeeH.-L.PeraR. R. (2012). Modeling Parkinson's disease using induced pluripotent stem cells. Curr. Neurol. Neurosci. Rep. 12, 237β242. 10.1007/s11910-012-0270-y22538490PMC3342500 | β | β | β |
| CaiJ.YangM.PoremskyE.KiddS.SchneiderJ. S.IacovittiL. (2009). Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev. 19, 1017β1023. 10.1089/scd.2009.031919824823PMC3135248 | β | β | β |
| CamnasioS.CarriA. D.LombardoA.GradI.MariottiC.CastucciA.. (2012). The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity. Neurobiol. Dis. 46, 41β51. 10.1016/j.nbd.2011.12.04222405424 | β | β | β |
| ChambersS. M.FasanoC. A.PapapetrouE. P.TomishimaM.SadelainM.StuderL. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275β280. 10.1038/nbt.152919252484PMC2756723 | β | β | β |
| CheahB. C.VucicS.KrishnanA. V.KiernanM. C. (2010). Riluzole, neuroprotection and amyotrophic lateral sclerosis. Curr. Med. Chem. 17, 1942β1959. 10.2174/09298671079116393920377511 | β | β | β |
| ChestkovI. V.VasilievaE. A.IllarioshkinS. N.LagarkovaM. A.KiselevS. L. (2014). Patient-specific induced pluripotent stem cells for SOD1-associated amyotrophic lateral sclerosis pathogenesis studies. Acta Naturae. 6, 54β60. 24772327PMC3999466 | β | β | β |
| ChiltonJ. K. (2006). Molecular mechanisms of axon guidance. Dev. Biol. 292, 13β24. 10.1016/j.ydbio.2005.12.04816476423 | β | β | β |
| ChungS.LeungA.HanB.-S.ChangM.-Y.MoonJ.-I.KimC.-H.. (2009). Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell. 5, 646β658. 10.1016/j.stem.2009.09.01519951692PMC2788512 | β | β | β |
| CooperO.HargusG.DeleidiM.BlakA.OsbornT.MarlowE.. (2010). Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol. Cell. Neurosci. 45, 258β266. 10.1016/j.mcn.2010.06.01720603216PMC2945816 | β | β | β |
| CorreiaA. S.AnisimovS. V.LiJ.-Y.BrundinP. (2005). Stem cell-based therapy for Parkinson's disease. Ann. Med. 37, 487β498. 10.1080/0785389050032796716278162 | β | β | β |
| CummingsB. J.UchidaN.TamakiS. J.SalazarD. L.HooshmandM.SummersR.. (2005). Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc. Natl. Acad. Sci. U.S.A. 102, 14069β14074. 10.1073/pnas.050706310216172374PMC1216836 | β | β | β |
| DevineM. J.RytenM.VodickaP.ThomsonA. J.BurdonT.HouldenH.. (2011). Parkinson's disease induced pluripotent stem cells with triplication of the Ξ±-synuclein locus. Nat. Commun. 2:440. 10.1038/ncomms145321863007PMC3265381 | β | β | β |
| Di GiorgioF. P.CarrascoM. A.SiaoM. C.ManiatisT.EgganK. (2007). Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 10, 608β614. 10.1038/nn188517435754PMC3139463 | β | β | β |
| DimosJ. T.RodolfaK. T.NiakanK. K.WeisenthalL. M.MitsumotoH.ChungW.. (2008). Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321, 1218β1221. 10.1126/science.115879918669821 | β | β | β |
| DonnellyC. J.ZhangP. W.PhamJ. T.HaeuslerA. R.MistryN. A.VidenskyS.. (2013). RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron 80, 415β428. 10.1016/j.neuron.2013.10.01524139042PMC4098943 | β | β | β |
| DonnellyD. J.PopovichP. G. (2008). Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp. Neurol. 209, 378β388. 10.1016/j.expneurol.2007.06.00917662717PMC2692462 | β | β | β |
| DoulamesV. M.PlantG. W. (2016). Induced pluripotent stem cell therapies for cervical spinal cord injury. Int. J. Mol. Sci. 17:530. 10.3390/ijms1704053027070598PMC4848986 | β | β | β |
| DuanL. (2014). Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death. Mol. Neurodegener. 9:3. 10.1186/1750-1326-9-324401693PMC3896712 | β | β | β |
| DunnettS. B.CarterR. J.WattsC.TorresE. M.MahalA.MangiariniL.. (1998). Striatal transplantation in a transgenic mouse model of Huntington's disease. Exp. Neurol. 154, 31β40. 10.1006/exnr.1998.69269875265 | β | β | β |
| EgashiraT.YuasaS.FukudaK. (2011). Induced pluripotent stem cells in cardiovascular medicine. Stem Cells Int. 2011:348960. 10.4061/2011/34896021977041PMC3184500 | β | β | β |
| EvansM. J.KaufmanM. H. (1981). Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154β156. 724268110.1038/292154a0 | β | β | β |
| FerriA. L. M.LinW.MavromatakisY. E.WangJ. C.SasakiH.WhitsettJ. A.. (2007). Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development 134, 2761β2769. 10.1242/dev.00014117596284 | β | β | β |
| FieldsR. D.Stevens-GrahamB. (2002). New insights into neuron-glia communication. Science 298, 556β562. 10.1126/science.298.5593.55612386325PMC1226318 | β | β | β |
| FujiwaraN.ShimizuJ.TakaiK.ArimitsuN.SaitoA.KonoT.. (2013). Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells. Neurosci. Lett. 557(pt B), 129β134. 10.1016/j.neulet.2013.10.04324466594 | β | β | β |
| GanatY. M.CalderE. L.KriksS.NelanderJ.TuE. Y.JiaF.. (2012). Identification of embryonic stem cellβderived midbrain dopaminergic neurons for engraftment. J. Clin. Invest. 122, 2928β2939. 10.1172/JCI5876722751106PMC3408729 | β | β | β |
| GasserT. (2007). Update on the genetics of Parkinson's disease. Mov. Disord. 22, S343βS350. 10.1002/mds.2167618175395 | β | β | β |
| GilJ. M.RegoA. C. (2009). The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease. Brain Res. Rev. 59, 410β431. 10.1016/j.brainresrev.2008.12.00119118572 | β | β | β |
| GiorgettiA.MontserratN.AasenT.GonzalezF.RodrΓguez-Piz,Γ I.VassenaR.. (2009). Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell. 5:353. 10.1016/j.stem.2009.09.00819796614PMC2779776 | β | β | β |
| GonzΓ‘lezF.BouΓ©S.BelmonteJ. C. I. (2011). Methods for making induced pluripotent stem cells: reprogramming a la carte. Nat. Rev. Genet. 12, 231β242. 10.1038/nrg293721339765 | β | β | β |
| GrealishS.DiguetE.KirkebyA.MattssonB.HeuerA.BramoulleY.. (2014). Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson's Disease. Cell Stem Cell. 15, 653β665. 10.1016/j.stem.2014.09.01725517469PMC4232736 | β | β | β |
| GuoZ.ZhangL.WuZ.ChenY.WangF.ChenG. (2014). In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. Cell Stem Cell. 14, 188β202. 10.1016/j.stem.2013.12.00124360883PMC3967760 | β | β | β |
| HadadehO.BarruetE.PeirettiF.VerdierM.BernotD.HadjalY.. (2012). The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells. PLoS ONE 7:e49065. 10.1371/journal.pone.004906523145071PMC3493518 | β | β | β |
| HallettP. J.DeleidiM.AstradssonA.SmithG. A.CooperO.OsbornT. M.. (2015). Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell. 16, 269β274. 10.1016/j.stem.2015.01.01825732245PMC4462124 | β | β | β |
| HanF.WangW.ChenB.ChenC.LiS.LuX.. (2015). Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's disease. Cytotherapy 17, 665β679. 10.1016/j.jcyt.2015.02.00125747741 | β | β | β |
| HedgesE. C.MehlerV. J.NishimuraA. L. (2016). The use of stem cells to model amyotrophic lateral sclerosis and frontotemporal dementia: from basic research to regenerative medicine. Stem Cells Int. 2016:9279516. 10.1155/2016/927951626966440PMC4761393 | β | β | β |
| Heman-AckahS. M.BassettA. R.WoodM. J. A. (2016). Precision modulation of neurodegenerative disease-related gene expression in human iPSC-derived neurons. Sci. Rep. 6:28420. 10.1038/srep2842027341390PMC4920027 | β | β | β |
| HerbertsC. A.KwaM. S. G.HermsenH. P. H. (2011). Risk factors in the development of stem cell therapy. J. Transl. Med. 9:1. 10.1186/1479-5876-9-2921418664PMC3070641 | β | β | β |
| HochedlingerK.JaenischR. (2006). Nuclear reprogramming and pluripotency. Nature 441, 1061β1067. 10.1038/nature0495516810240 | β | β | β |
| HongJ. Y.LeeS. H.LeeS. C.KimJ.-W.KimK.-P.KimS. M.. (2014). Therapeutic potential of induced neural stem cells for spinal cord injury. J. Biol. Chem. 289, 32512β32525. 10.1074/jbc.M114.58887125294882PMC4239606 | β | β | β |
| HornerP. J.GageF. H. (2000). Regenerating the damaged central nervous system. Nature 407, 963β970. 10.1038/3503955911069169 | β | β | β |
| HouS.LuP. (2016). Direct reprogramming of somatic cells into neural stem cells or neurons for neurological disorders. Neural Regen. Res. 11, 28β31. 10.4103/1673-5374.16960226981072PMC4774217 | β | β | β |
| HoweS. J.MansourM. R.SchwarzwaelderK.BartholomaeC.HubankM.KempskiH.. (2008). Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J. Clin. Invest. 118, 3143β3150. 10.1172/jci3579818688286PMC2496964 | β | β | β |
| HuangfuD.MaehrR.GuoW.EijkelenboomA.SnitowM.ChenA. E.. (2008). Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 26, 795β797. 10.1038/nbt141818568017PMC6334647 | β | β | β |
| HuZ.PuJ.JiangH.ZhongP.QiuJ.LiF.. (2015). Generation of naivetropic induced pluripotent stem cells from Parkinson's disease patients for high-efficiency genetic manipulation and disease modeling. Stem Cells Dev. 24, 2591β2604. 10.1089/scd.2015.007926218671PMC4620536 | β | β | β |
| IkegamiT.NakamuraM.YamaneJ.KatohH.OkadaS.IwanamiA.. (2005). Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. Eur. J. Neurosci. 22, 3036β3046. 10.1111/j.1460-9568.2005.04492.x16367770 | β | β | β |
| IsraelM. A.YuanS. H.BardyC.ReynaS. M.MuY.HerreraC.. (2012). Probing sporadic and familial Alzheimer/'s disease using induced pluripotent stem cells. Nature 482, 216β220. 10.1038/nature1082122278060PMC3338985 | β | β | β |
| JonesL. L.OudegaM.BungeM. B.TuszynskiM. H. (2001). Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. J. Physiol. 533, 83β89. 10.1111/j.1469-7793.2001.0083b.x11351016PMC2278599 | β | β | β |
| KangX.XuH.TengS.ZhangX.DengZ.ZhouL.. (2014). Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc. Natl. Acad. Sci. U.S.A. 111, 15804β15809. 10.1073/pnas.140848411125331880PMC4226131 | β | β | β |
| KarchC. M.GoateA. M. (2015). Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol. Psychiatry 77, 43β51. 10.1016/j.biopsych.2014.05.00624951455PMC4234692 | β | β | β |
| KayeJ. A.FinkbeinerS. (2013). Modeling Huntington's Disease with induced pluripotent stem cells. Mol. Cell. Neurosci. 56, 50β64. 10.1016/j.mcn.2013.02.00523459227PMC3791169 | β | β | β |
| KellerG. M. (1995). In vitro differentiation of embryonic stem cells. Curr. Opin. Cell Biol. 7, 862β869. 10.1016/0955-0674(95)80071-98608017 | β | β | β |
| KhodosevichK.MonyerH. (2011). Signaling in migrating neurons: from molecules to networks. Front. Neurosci. 5:28. 10.3389/fnins.2011.0002821629825PMC3096852 | β | β | β |
| KimeC.MandegarM. A.SrivastavaD.YamanakaS.ConklinB. R.RandT. A. (2016). Efficient CRISPR/Cas9-Based genome engineering in human pluripotent stem cells. Curr. Protoc. Hum. Genet 88, Unit 21.24. 10.1002/0471142905.hg2104s8826724721PMC4726454 | β | β | β |
| KimS. M.FlaΓkampH.HermannA.AraΓΊzo-BravoM. J.LeeS. C.LeeS. H.. (2014). Direct conversion of mouse fibroblasts into induced neural stem cells. Nat. Protoc. 9, 871β881. 10.1038/nprot.2014.05624651499 | β | β | β |
| KittappaR.ChangW. W.AwatramaniR. B.McKayR. D. G. (2007). The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol. 5:e325. 10.1371/journal.pbio.005032518076286PMC2121110 | β | β | β |
| LancasterM. A.KnoblichJ. A. (2014). Generation of cerebral organoids from human pluripotent stem cells. Nat. Protoc. 9, 2329β2340. 10.1038/nprot.2014.15825188634PMC4160653 | β | β | β |
| LauS.Rylander OttossonD.JakobssonJ.ParmarM. (2014). Direct neural conversion from human fibroblasts using self-regulating and nonintegrating viral vectors. Cell Rep. 9, 1673β1680. 10.1016/j.celrep.2014.11.01725482564 | β | β | β |
| LiJ. Y.PopovicN.BrundinP. (2005). The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx 2, 447β464. 10.1602/neurorx.2.3.44716389308PMC1144488 | β | β | β |
| LindborgB. A.BrekkeJ. H.VegoeA. L.UlrichC. B.HaiderK. T.SubramaniamS.. (2016). Rapid Induction of cerebral organoids from human induced pluripotent stem cells using a chemically defined hydrogel and defined cell culture medium. Stem Cells Transl. Med. 5, 970β979. 10.5966/sctm.2015-030527177577PMC4922855 | β | β | β |
| LiveseyM. R. (2016). Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes. Stem Cells. 34, 1040β1053. 10.1002/stem.227326763608PMC4840312 | β | β | β |
| LiX.-J.ZhangX.JohnsonM. A.WangZ.-B.LaVauteT.ZhangS.-C. (2009). Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development 136, 4055β4063. 10.1242/dev.03662419906872PMC2778748 | β | β | β |
| LiY.BalasubramanianU.CohenD.ZhangP.-W.MosmillerE.SattlerR.. (2015). A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells. PLoS ONE 10:e0118266. 10.1371/journal.pone.011826625760436PMC4356618 | β | β | β |
| LoB.ParhamL. (2009). Ethical issues in stem cell research. Endocr. Rev. 30, 204β213. 10.1210/er.2008-003119366754PMC2726839 | β | β | β |
| Lopez-LeonM.ReggianiP. C.HerenuC. B.GoyaR. G. (2014). Regenerative medicine for the aging brain. Enliven. J. Stem Cell Res. Regen. Med. 1, 1β9. 25699290PMC4330563 | β | β | β |
| MallannaS. K.RizzinoA. (2010). Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells. Dev. Biol. 344, 16β25. 10.1016/j.ydbio.2010.05.01420478297PMC2935203 | β | β | β |
| MandegarM. A.HuebschN.FrolovE. B.ShinE.TruongA.OlveraM. P.. (2016). CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. 18, 541β553. 10.1016/j.stem.2016.01.02226971820PMC4830697 | β | β | β |
| MangiariniL.SathasivamK.SellerM.CozensB.HarperA.HetheringtonC.. (1996). Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493β506. 10.1016/S0092-8674(00)81369-08898202 | β | β | β |
| MartinG. R. (1981). Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. U.S.A. 78, 7634β7638. 695040610.1073/pnas.78.12.7634PMC349323 | β | β | β |
| MiuraK.OkadaY.AoiT.OkadaA.TakahashiK.OkitaK.. (2009). Variation in the safety of induced pluripotent stem cell lines. Nat. Biotechnol. 27, 743β745. 10.1038/nbt.155419590502 | β | β | β |
| MorizaneA.KikuchiT.NishimuraK.TakahashiJ. (2011). Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells. J. Neurosci. Res. 89, 117β126. 10.1002/jnr.2254721162120 | β | β | β |
| MungenastA. E.SiegertS.TsaiL. H. (2016). Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells. Mol. Cell. Neurosci. 73, 13β31. 10.1016/j.mcn.2015.11.01026657644PMC5930170 | β | β | β |
| NagaiM.ReD. B.NagataT.ChalazonitisA.JessellT. M.WichterleH.. (2007). Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat. Neurosci. 10, 615β622. 10.1038/nn187617435755PMC3799799 | β | β | β |
| NakamuraM.OkanoH. (2013). Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells. Cell Res. 23, 70β80. 10.1038/cr.2012.17123229514PMC3541652 | β | β | β |
| NekrasovE. D.VigontV. A.KlyushnikovS. A.LebedevaO. S.VassinaE. M.BogomazovaA. N.. (2016). Manifestation of Huntington's disease pathology in human induced pluripotent stem cell-derived neurons. Mol. Neurodegener. 11:27. 10.1186/s13024-016-0092-527080129PMC4832474 | β | β | β |
| NicholasC. R.ChenJ.TangY.SouthwellD. G.ChalmersN.VogtD.. (2013). Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell 12, 573β586. 10.1016/j.stem.2013.04.00523642366PMC3699205 | β | β | β |
| NiewegK.AndreyevaA.van StegenB.TanriΓΆverG.GottmannK. (2015). Alzheimer's disease-related amyloid-Ξ² induces synaptotoxicity in human iPS cell-derived neurons. Cell Death Dis. 6:e1709. 10.1038/cddis.2015.7225837485PMC4650541 | β | β | β |
| NiwaH. (2007). How is pluripotency determined and maintained? Development 134, 635β646. 10.1242/dev.0278717215298 | β | β | β |
| NoriS.OkadaY.NishimuraS.SasakiT.ItakuraG.KobayashiY.. (2015). Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Reports 4, 360β373. 10.1016/j.stemcr.2015.01.00625684226PMC4375796 | β | β | β |
| OkanoH.NakamuraM.YoshidaK.OkadaY.TsujiO.NoriS.. (2013). Steps toward safe cell therapy using induced pluripotent stem cells. Circ. Res. 112, 523β533. 10.1161/circresaha.111.25614923371901 | β | β | β |
| OkiK.TatarishviliJ.WoodJ.KochP.WattananitS.MineY.. (2012). Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Stem Cells 30, 1120β1133. 10.1002/stem.110422495829 | β | β | β |
| OkitaK.IchisakaT.YamanakaS. (2007). Generation of germline-competent induced pluripotent stem cells. Nature 448, 313β317. 10.1038/nature0593417554338 | β | β | β |
| PagliucaF. W.MillmanJ. R.GΓΌrtlerM.SegelM.Van DervortA.RyuJ. H.. (2014). Generation of functional human pancreatic Ξ² cells in vitro. Cell 159, 428β439. 10.1016/j.cell.2014.09.04025303535PMC4617632 | β | β | β |
| PajerK.NemesC.BerzsenyiS.KovΓ‘csK. A.PirityM. K.PajendaG.. (2015). Grafted murine induced pluripotent stem cells prevent death of injured rat motoneurons otherwise destined to die. Exp. Neurol. 269, 188β201. 10.1016/j.expneurol.2015.03.03125889458 | β | β | β |
| PaquetD.KwartD.ChenA.SproulA.JacobS.TeoS.. (2016). Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9. Nature 533, 125β129. 10.1038/nature1766427120160 | β | β | β |
| ParkI.-H.AroraN.HuoH.MaheraliN.AhfeldtT.ShimamuraA.. (2008a). Disease-specific induced pluripotent stem cells. Cell 134, 877β886. 10.1016/j.cell.2008.07.04118691744PMC2633781 | β | β | β |
| ParkI.-H.ZhaoR.WestJ. A.YabuuchiA.HuoH.InceT. A.. (2008b). Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451, 141β146. 10.1038/nature0653418157115 | β | β | β |
| ParrA. M.KulbatskiI.ZahirT.WangX.YueC.KeatingA.. (2008). Transplanted adult spinal cordβderived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience 155, 760β770. 10.1016/j.neuroscience.2008.05.04218588947 | β | β | β |
| PeiD.XuJ.ZhuangQ.TseH.-F.EstebanM. A. (2010). Induced pluripotent stem cell technology in regenerative medicine and biology, in Bioreactor Systems for Tissue Engineering II, Vol. 123, eds KasperC.Van GriensvenM.PΓΆrtnerR. (New York: Springer), 127β141.10.1007/10_2010_7220549468 | β | β | β |
| PlantG. W.BatesM. L.BungeM. B. (2001). Inhibitory proteoglycan immunoreactivity is higher at the caudal than the rostral Schwann cell graft-transected spinal cord interface. Mol. Cell. Neurosci. 17, 471β487. 10.1006/mcne.2000.094811273643 | β | β | β |
| QiangL.FujitaR.YamashitaT.AnguloS.RhinnH.RheeD.. (2011). Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons. Cell 146, 359β371. 10.1016/j.cell.2011.07.00721816272PMC3151530 | β | β | β |
| QuadratoG.BrownJ.ArlottaP. (2016). The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat. Med. 22, 1220β1228. 10.1038/nm.421427783065 | β | β | β |
| RaabS.KlingensteinM.LiebauS.LintaL. (2014). A comparative view on human somatic cell sources for iPSC generation. Stem Cells Int. 2014:12. 10.1155/2014/76839125431601PMC4241335 | β | β | β |
| RaismanG. (2001). Olfactory ensheathing cellsβanother miracle cure for spinal cord injury? Nat. Rev. Neurosci. 2, 369β375. 10.1038/3507257611331921 | β | β | β |
| RamerL. M.AuE.RichterM. W.LiuJ.TetzlaffW.RoskamsA. J. (2004). Peripheral olfactory ensheathing cells reduce scar and cavity formation and promote regeneration after spinal cord injury. J. Comp. Neurol. 473, 1β15. 10.1002/cne.2004915067714 | β | β | β |
| RheeY. H.KoJ. Y.ChangM. Y.YiS. H.KimD.KimC. H.. (2011). Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J. Clin. Invest. 121, 2326β2335. 10.1172/jci4579421576821PMC3104759 | β | β | β |
| RoesslerR.SmallwoodS. A.VeenvlietJ. V.PechlivanoglouP.PengS. P.ChakrabartyK.. (2014). Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons. Stem Cell Reports 2, 520β533. 10.1016/j.stemcr.2014.03.00124749075PMC3986662 | β | β | β |
| RomanyukN.AmemoriT.TurnovcovaK.ProchazkaP.OntenienteB.SykovaE.. (2015). Beneficial effect of human induced pluripotent stem cell-derived neural precursors in spinal cord injury repair. Cell Transplant. 24, 1781β1797. 10.3727/096368914X68404225259685 | β | β | β |
| RubioA.LuoniM.GiannelliS. G.RadiceI.IannielliA.CancellieriC.. (2016). Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming. Sci. Rep. 6:37540. 10.1038/srep3754027857203PMC5114606 | β | β | β |
| RyanS. D.DolatabadiN.ChanS. F.ZhangX.AkhtarM. W.ParkerJ.. (2013). Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1Ξ± transcription. Cell 155, 1351β1364. 10.1016/j.cell.2013.11.00924290359PMC4028128 | β | β | β |
| SancesS.BruijnL.ChandranS.EgganK.HoR.KlimJ.. (2016). Modeling ALS using motor neurons derived from human induced pluripotent stem cells. Nat. Neurosci. 19, 542β553. 10.1038/nn.427327021939PMC5015775 | β | β | β |
| SareenD.O'RourkeJ. G.MeeraP.MuhammadA.GrantS.SimpkinsonM.. (2013). Targeting RNA foci in iPSC-derived motor neurons from ALS patients with C9ORF72 repeat expansion. Sci. Transl. Med. 5:208ra149. 10.1126/scitranslmed.300752924154603PMC4090945 | β | β | β |
| ScheiffeleP. (2003). Cell-cell signaling during synapse formation in the CNS. Annu. Rev. Neurosci. 26, 485β508. 10.1146/annurev.neuro.26.043002.09494012626697 | β | β | β |
| SchulzJ. B. (2008). Update on the pathogenesis of Parkinson's disease. J. Neurol. 255 (Suppl. 5), 3β7. 10.1007/s00415-008-5011-418787877 | β | β | β |
| SerioA.BilicanB.BarmadaS. J.AndoD. M.ZhaoC.SillerR.. (2013). Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc. Natl. Acad. Sci. U.S.A. 110, 4697β4702. 10.1073/pnas.130039811023401527PMC3607024 | β | β | β |
| SerrettiA.OlgiatiP.De RonchiD. (2007). Genetics of Alzheimer's disease. A rapidly evolving field. J. Alzheimers Dis. 12, 73β92. 1785119610.3233/jad-2007-12108 | β | β | β |
| SoldnerF.HockemeyerD.BeardC.GaoQ.BellG. W.CookE. G.. (2009). Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136, 964β977. 10.1016/j.cell.2009.02.01319269371PMC2787236 | β | β | β |
| SonntagK. C.PruszakJ.YoshizakiT.van ArensbergenJ.Sanchez-PernauteR.IsacsonO. (2007). Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells 25, 411β418. 10.1634/stemcells.2006-038017038668PMC2667240 | β | β | β |
| SproulA. A. (2015). Being human: the role of pluripotent stem cells in regenerative medicine and humanizing Alzheimer's disease models. Mol. Aspects Med. 43, 54β65. 10.1016/j.mam.2015.06.00726101165 | β | β | β |
| SuR. J.NeisesA.ZhangX. B. (2016). Generation of iPS cells from human peripheral blood mononuclear cells using episomal vectors. Methods Mol. Biol. 1357, 57β69. 10.1007/7651_2014_13925403468 | β | β | β |
| SurmaczB.NoisaP.Risner-JaniczekJ. R.HuiK.UnglessM.CuiW.. (2012). DLK1 promotes neurogenesis of human and mouse pluripotent stem cell-derived neural progenitors via modulating Notch and BMP signalling. Stem Cell Rev. 8, 459β471. 10.1007/s12015-011-9298-721761283 | β | β | β |
| SΓ‘nchez-DanΓ©sA.Richaud-PatinY.Carballo-CarbajalI.JimΓ©nez-DelgadoS.CaigC.MoraS.. (2012). Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. EMBO Mol. Med. 4, 380β395. 10.1002/emmm.20120021522407749PMC3403296 | β | β | β |
| TakahashiK.TanabeK.OhnukiM.NaritaM.IchisakaT.TomodaK.. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861β872. 10.1016/j.cell.2007.11.01918035408 | β | β | β |
| TakahashiK.YamanakaS. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663β676. 10.1016/j.cell.2006.07.02416904174 | β | β | β |
| The International Stem Cell Consortium InitiativeAkopianV.AndrewsP. W.BeilS.BenvenistyN.BrehmJ.. (2010). Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells. In Vitro Cell. Dev. Biol. Anim. 46, 247β258. 10.1007/s11626-010-9297-z20186512PMC2855804 | β | β | β |
| ThomsonJ. A.Itskovitz-EldorJ.ShapiroS. S.WaknitzM. A.SwiergielJ. J.MarshallV. S.. (1998). Embryonic stem cell lines derived from human blastocysts. Science (New York, NY). 282, 1145β1147. 10.1126/science.282.5391.11459804556 | β | β | β |
| TousleyA.Kegel-GleasonK. B. (2016). Induced pluripotent stem cells in Huntington's disease research: progress and opportunity. J. Huntingtons. Dis. 5, 99β131. 10.3233/jhd-16019927372054PMC4942721 | β | β | β |
| TrounsonA.DeWittN. D. (2016). Pluripotent stem cells progressing to the clinic. Nat. Rev. Mol. Cell Biol. 17, 194β200. 10.1038/nrm.2016.1026908143 | β | β | β |
| TsubookaN.IchisakaT.OkitaK.TakahashiK.NakagawaM.YamanakaS. (2009). Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts. Genes Cells 14, 683β694. 10.1111/j.1365-2443.2009.01301.x19476507 | β | β | β |
| TsujiO.MiuraK.OkadaY.FujiyoshiK.MukainoM.NagoshiN.. (2010). Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 107, 12704β12709. 10.1073/pnas.091010610720615974PMC2906548 | β | β | β |
| UnternaehrerJ. J.DaleyG. Q. (2011). Induced pluripotent stem cells for modelling human diseases. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 366, 2274β2285. 10.1098/rstb.2011.001721727133PMC3130418 | β | β | β |
| WangY.BaskervilleS.ShenoyA.BabiarzJ. E.BaehnerL.BlellochR. (2008). Embryonic stem cellβspecific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat. Genet. 40, 1478β1483. 10.1038/ng.25018978791PMC2630798 | β | β | β |
| WenkerS. D.CasalΓaM.CandedoV. C.CasabonaJ. C.PitossiF. J. (2015). Cell reprogramming and neuronal differentiation applied to neurodegenerative diseases: focus on Parkinson's disease. FEBS Lett. 589, 3396β3406. 10.1016/j.febslet.2015.07.02326226418 | β | β | β |
| WernigM.MeissnerA.ForemanR.BrambrinkT.KuM.HochedlingerK.. (2007). In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318β324. 10.1038/nature0594417554336 | β | β | β |
| WernigM.ZhaoJ. P.PruszakJ.HedlundE.FuD.SoldnerF.. (2008). Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 105, 5856β5861. 10.1073/pnas.080167710518391196PMC2311361 | β | β | β |
| YagiT.ItoD.OkadaY.AkamatsuW.NiheiY.YoshizakiT.. (2011). Modeling familial Alzheimer's disease with induced pluripotent stem cells. Hum. Mol. Genet. 20, 4530β4539. 10.1093/hmg/ddr39421900357 | β | β | β |
| YahataN.AsaiM.KitaokaS.TakahashiK.AsakaI.HiokiH.. (2011). Anti-AΞ² drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS ONE 6:e25788. 10.1371/journal.pone.002578821984949PMC3184175 | β | β | β |
| YangC. R.YuR. K. (2009). Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease. J. Neurosci. Res. 87, 26β33. 10.1002/jnr.2181718683244PMC3895944 | β | β | β |
| YangJ.LiS.HeX.-B.ChengC.LeW. (2016). Induced pluripotent stem cells in Alzheimer's disease: applications for disease modeling and cell-replacement therapy. Mol. Neurodegener. 11:39. 10.1186/s13024-016-0106-327184028PMC4869261 | β | β | β |
| ZaehresH.KoglerG.Arauzo-BravoM. J.BleidisselM.SantourlidisS.WeinholdS.. (2010). Induction of pluripotency in human cord blood unrestricted somatic stem cells. Exp. Hematol. 38, 809β818, 818.e801-802. 10.1016/j.exphem.2010.05.00920541586 | β | β | β |
| ZhangN.AnM. C.MontoroD.EllerbyL. M. (2010). Characterization of human Huntington's disease cell model from induced pluripotent stem cells. PLoS Curr. 2:RRN1193. 10.1371/currents.RRN119321037797PMC2966296 | β | β | β |
| ZhaoY.YinX.QinH.ZhuF.LiuH.YangW.. (2008). Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell. 3, 475β479. 10.1016/j.stem.2008.10.00218983962 | β | β | β |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | 2019 | 30087005 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Recent progress in CRISPR-Cas-system for neurological disorders. | Mishra S et al. | β | 2025 | β |
| Tau aggregation induces cell death in iPSC-derived neurons. | Tanabe H et al. | β | 2025 | β |
| Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells. | Sheeler C et al. | β | 2024 | β |
| In vivo and ex vivo gene therapy for neurodegenerative diseases: a promise for disease modification. | Ebrahimi P et al. | β | 2024 | β |
| Stem Cell Therapy and Thiamine Deficiency-Induced Brain Damage. | Hazell AS | β | 2024 | β |
| USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons. | Okarmus J et al. | β | 2024 | β |
| Brain organoids and organoid intelligence from ethical, legal, and social points of view. | Hartung T et al. | β | 2023 | β |
| Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through. | Jusop AS et al. | β | 2023 | β |
| Differentiation of hPSCs to Study PRC2 Role in Cell-Fate Specification and Neurodevelopment. | Brocchetti S et al. | β | 2023 | β |
| Different iPSC-derived neural stem cells shows various spectrums of spontaneous differentiation during long term cultivation. | Galiakberova AA et al. | β | 2023 | β |
| Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters. | Tam RW et al. | β | 2023 | β |
| Stem Cells and Natural Agents in the Management of Neurodegenerative Diseases: A New Approach. | Brockmueller A et al. | β | 2023 | β |
| USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons | Okarmus J et al. | β | 2023 | β |
| Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming. | Legault EM et al. | β | 2022 | β |
| iPSCs and DRGs: stepping stones to new pain therapies. | Alsaloum M et al. | β | 2022 | β |
| Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer's Disease Pathology, Constitute a Potential Object for Early Diagnosis. | Lopez-Toledo G et al. | β | 2022 | β |
| Current Approaches and Molecular Mechanisms for Directly Reprogramming Fibroblasts Into Neurons and Dopamine Neurons. | Han F et al. | β | 2021 | β |
| <i>NGN2</i> mmRNA-Based Transcriptional Programming in Microfluidic Guides hiPSCs Toward Neural Fate With Multiple Identities. | Tolomeo AM et al. | β | 2021 | β |
| New Avenues for the Treatment of Huntington's Disease. | Kim A et al. | β | 2021 | β |
| Patient-Derived Induced Pluripotent Stem Cell Models for Phenotypic Screening in the Neuronal Ceroid Lipofuscinoses. | Morsy A et al. | β | 2021 | β |
| 3D Printed Conductive Nanocellulose Scaffolds for the Differentiation of Human Neuroblastoma Cells. | Bordoni M et al. | β | 2020 | β |
| Advancement in the modelling and therapeutics of Parkinson's disease. | Rai SN et al. | β | 2020 | β |
| Chromatin Interaction Changes during the iPSC-NPC Model to Facilitate the Study of Biologically Significant Genes Involved in Differentiation. | Choi WY et al. | β | 2020 | β |
| DNF: A differential network flow method to identify rewiring drivers for gene regulatory networks. | Xie J et al. | β | 2020 | β |
| Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders. | Murtaza N et al. | β | 2020 | β |
| "LRRK2: Autophagy and Lysosomal Activity". | Madureira M et al. | β | 2020 | β |
| Microglia: Agents of the CNS Pro-Inflammatory Response. | RodrΓguez-GΓ³mez JA et al. | β | 2020 | β |
| Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells. | Hu X et al. | β | 2020 | β |
| Modulation of Stem Cells as Therapeutics for Severe Mental Disorders and Cognitive Impairments. | Zhang Y et al. | β | 2020 | β |
| Pathological manifestation of the induced pluripotent stem cell-derived cortical neurons from an early-onset Alzheimer's disease patient carrying a presenilin-1 mutation (S170F). | Li L et al. | β | 2020 | β |
| Perspective: Current Pitfalls in the Search for Future Treatments and Prevention of Parkinson's Disease. | Poortvliet PC et al. | β | 2020 | β |
| Automated four-dimensional long term imaging enables single cell tracking within organotypic brain slices to study neurodevelopment and degeneration. | Linsley JW et al. | β | 2019 | β |
| Human Embryonic Stem Cell-Derived Neural Lineages as <i>In Vitro</i> Models for Screening the Neuroprotective Properties of <i>Lignosus rhinocerus</i> (Cooke) Ryvarden. | Yeo Y et al. | β | 2019 | β |
| Mitochondria as central regulators of neural stem cell fate and cognitive function. | Khacho M et al. | β | 2019 | β |
| Progress in the Use of Induced Pluripotent Stem Cell-Derived Neural Cells for Traumatic Spinal Cord Injuries in Animal Populations: Meta-Analysis and Review. | Ramotowski C et al. | β | 2019 | β |
| Regulation of Neural Stem Cell Fate by Natural Products. | Kim HJ | β | 2019 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Using induced pluripotent stem cells for modeling Parkinson's disease. | Ke M et al. | β | 2019 | β |
| A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and <i>in vivo</i> tracking of therapeutic cells. | Lopez-Yrigoyen M et al. | β | 2018 | β |
| A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA. | Little D et al. | β | 2018 | β |
| Cold atmospheric plasma (CAP), a novel physicochemical source, induces neural differentiation through cross-talk between the specific RONS cascade and Trk/Ras/ERK signaling pathway. | Jang JY et al. | β | 2018 | β |
| Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases. | Joshi AU et al. | β | 2018 | β |
| On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations. | Wu S et al. | β | 2018 | β |
| Plate-Based Phenotypic Screening for Pain Using Human iPSC-Derived Sensory Neurons. | Stacey P et al. | β | 2018 | β |
| The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials. | Pohl F et al. | β | 2018 | β |
| Towards better cellular replacement therapies in Parkinson disease. | Sun AX et al. | β | 2018 | β |
| The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. | Gonzalez DM et al. | β | 2017 | β |