can be easily obtained from patients through biopsy and are relatively inexpensive and widely commercially available by many companies. However, the fact that fibroblasts are highly proliferative poses few disadvantages as the non-programmed fibroblasts can have the opportunity to overgrow the existing reprogrammed cells and consume the growth factors in the media. This can usually be overcome by using a low passage not exceeding passage 5 in order to avoid accumulated genomic changes (Raab et al., 2014).
