Among different groundbreaking experiments, the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) endonuclease is considered the less cumbersome and the most flexible system to execute precise genome editing in human pluripotent stem cells (Kime et al., 2016). The genomic revolution made by this system and others, including the Zinc Finger Nucleases (ZFN) and Site specific nucleases (SPN), offered the simplest and most powerful approach toward manipulating the produced iPSCs for mimicking any disease and adding more advancement and efficiency to the resulting cells (Mandegar et al., 2016). Recently, Rubio et al. described a new platform where neurons can be generated in vitro and manipulated using CRISPR/Cas9 to inactivate specific genes associated with different neuropathologies in humans (Rubio et al., 2016). Moreover, in a recent study, it was shown that CRISPR can be used to exert precise alterations in the expression of the critical PD-related gene, SNCA, in human iPSC-derived neurons (Heman-Ackah et al., 2016). Remarkably, Paquet et al. (2016) established a procedure that allows the introduction of specific point mutations into iPSCs using CRISPR, thus generating human iPSCs with specific
