of the critical PD-related gene, SNCA, in human iPSC-derived neurons (Heman-Ackah et al., 2016). Remarkably, Paquet et al. (2016) established a procedure that allows the introduction of specific point mutations into iPSCs using CRISPR, thus generating human iPSCs with specific combinations of homozygous and heterozygous early-onset Alzheimer's-associated mutations. Certainly, the rapid development of iPSCs and genome-editing technologies are important tools for disease modeling that hold promise for applications in gene therapy.
