Chunk #39 — Future directions – addressing the neural circuit by genetic approaches — New animal models

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15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse.

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Ultimately, the combination of emerging technologies at molecular, circuit and behavioral levels holds enormous potential to discover novel mechanisms operating at integrated level. The opioid system remains a prime candidate to develop successful therapies in addicted individuals, and understanding opioid-mediated processes at systems levels represents a challenging goal in addiction research.