In the analysis by sex, no significant allele frequency difference existed for either sex between those with and without depression in any of the single studies or in the meta-analysis of all studies within either sex or for sexes combined (female sex: OR, 1.07; 95% CI, 0.96-1.18; male sex: OR, 1.00; 95% CI, 0.87-1.14, all participants: OR, 1.04; 95% CI, 0.96-1.13; Figure 3A). Thus, the genotype alone did not predict depression.