Similar to the results of Table 2 for the specific number of life events, the meta-analysis shows that the number of stressful life events was significantly associated with depression (OR, 1.40; 95% CI, 1.25-1.57; Figure 2B). Finally, in the analysis of interaction (Figure 2C), the ORs were significant for the studies of Caspi et al10 and Wilhelm et al27 but were not significant for any of the other replication studies. The aggregate estimate did not yield a significant interaction (OR, 1.01; CI, 0.94- 1.10) indicating that 5-HTTLPR genotype did not interact with stressful life events on the risk of depression.
