that the physiological-noise (include respiratory and cardiac frequencies) are completely filtered. These remaining signals after filtering are used to perform subsequent data analysis. Three different analyses of gender-specific effects of hemispheric asymmetry in PFC were performed with processed fOT data that include: 1) functional connectivity, 2) cortical lateralization and 3) significant differences analysis. All of the data were analyzed with group-level brain functional response of PFC area in resting-state.