While the interaction between rs604300 genotype and CA reached significance in SAGE, there are several caveats to interpreting this replication. First, due to the low prevalence of CSA (20.0%), childhood abuse was defined in SAGE as exposure to sexual or physical abuse. This is in contrast to CATS, where individuals reported experiencing 1.57 CSA events on average. These substantial differences in childhood abuse experiences across samples could have resulted in the regions of significance differing across studies (i.e., genotype effects only at higher levels of CSA in CATS and only among the no-CA group in SAGE and low ELS group in DNS). Furthermore, due to heterogeneous measurement of CA across the studies contributing to the SAGE sample, CA was dichotomized (present versus absent), thus resulting in a loss of power when compared to the continuous measure used in CATS. Relatedly, as the minor allele is rare, AA and AG individuals were combined in SAGE. As shown in Figures S5 and S6, restricting the sample to CSA alone or examining AA and AG individuals separately did not alter the nature of
