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Chunk #54 — Discussion — Limitations

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Monoacylglycerol lipase (MGLL) polymorphism rs604300 interacts with childhood adversity to predict cannabis dependence symptoms and amygdala habituation: Evidence from an endocannabinoid system-level analysis.
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as the minor allele is rare, AA and AG individuals were combined in SAGE. As shown in Figures S5 and S6, restricting the sample to CSA alone or examining AA and AG individuals separately did not alter the nature of the interaction; however, we did not consider these findings to be reliable due to the modest sample size (Table S3). Conversely, assuming a dominant model in CATS (i.e., examining AA/AG individuals together) or using a combined measure of childhood physical and sexual abuse resulted in little change to the nature or significance of the interaction (dominant model: bGxE = -4.62, 95% CI [-7.01, -2.22], ΔR2 = .008, ΔF(1,1527) = 14.29, p = .0002; combined CSA and CPA: bGxE = -3.18, 95% CI [-6.23, -0.13], ΔR2 = .002, ΔF(1,1527) = 4.18, p = .041).