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Chunk #57 — Discussion — Limitations and Conclusions

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Alcohol-related genes show an enrichment of associations with a persistent externalizing factor.
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original set could not be included, nor could potential rare causal variants not present on the chip. The personality measures were only available at five of the eleven waves and by the final wave, data was missing on a majority of participants, meaning that the information contributing to the full model was incomplete; nevertheless, we used robust methods for handling missing data. Lastly, our analyses did not include individuals from ancestral backgrounds other than non-Hispanic Whites, because we sought to eliminate population stratification confounds, limiting the generalizability of these findings to the broader population.