These results provide further evidence that variation in this set of 104 genes is associated with Persistent Externalizing within the non-Hispanic White population, a demonstration of our advantageous approach to bridging the gap between genetic variation and complex behavior. Bioinformatics approaches could be used to ascertain if these genes operate within a confined network, or if multiple gene networks, perhaps serving distinct neural systems, are present within this set of genes. Identifying these networks and neural systems may yield greater insight into the origins of broad externalizing traits and behavior, which may be fruitful for understanding the shared biological origins of a number of clinical disorders on the externalizing spectrum.
