A follow-up to the above cited study in the same sample reported association between rs2302763 in CHRNB1 and smoking quantity in EA (Lou et al., 2006). We did not test this specific SNP, but genotyped other highly correlated SNPs according to HapMap Centre d’Etudie du Polymorphisme Humain (CEPH) from Utah (CEU) data (The International HapMap Consortium, 2005) (e.g. rs2302765, rs4796418, rs3855924). None were associated with nicotine dependence in our sample. We do observe a separate, nominally significant signal in CHRNB1 tagged by rs17732878; this LD bin is not correlated with rs2302763 (HapMap CEU r2 < 0.06).
