A study of 39 SNPs in 11 CHRN genes in Israeli women reported main effects of rs2072660 (CHRNB2) with history of daily smoking, and of rs1909884 (CHRNA7), rs4861065 (CHRNA9), and rs9298629 (CHRNB3) with nicotine dependence (Greenbaum et al., 2006). Our sample provides weak support for rs9298629 (p = 0.019). Another study reported associations between subjective reactions to cigarettes and rs2072660 and rs2072658 in CHRNB2, in Caucasian and Hispanic young adults (Ehringer et al., 2007). We do not see association between these SNPs and nicotine dependence in our sample.
