We additionally tested rs9829896 as a trans-eQTL for the µ-opioid receptor (OPRM1) gene transcript, even though it is not part of the GeneMANIA identified gene network, given this gene’s suggested role in the cAMP pathway and drug addiction.(Gris et al., 2010; Zhang et al., 2013) Similar to the eQTL patterns observed for KAT2B and CREBBP, rs9829896 was associated with OPRM1 expression in AAs (P=0.016) but not in EAs (P=0.12). The drug abuse protective rs9829896-C allele was associated with higher OPRM1 expression (Figure 2c).
