We also identified a region on chromosome 9 within the DAB2IP gene encompassing two SNPs that were associated with increased heart rate. This gene encodes a GTPase-activating protein and is an inhibitor of cell growth and survival. DAB2IP has been identified by a GWAS for an association with prostate cancer in European and African descent populations (Gretarsdottir et al. 2010). Recently, a GWAS of individuals from Iceland and the Netherlands identified an association with DAB2IP with abdominal aortic aneurysms and other vascular diseases including early onset myocardial infarction (Gretarsdottir et al. 2010).
