Four of the five generalizations we identified in African Americans are located in voltage-gated channels (Table 3). For PR interval, we compared the SCN5A/SCN10 region association results in African Americans with previously identified European Americans (also ascertained from VGER; Supplementary Fig. 2)(Denny et al. 2010). Though not significant, the index SNP identified in Europeans was different compared to African Americans. This is likely due to differences in linkage disequilibrium patterns between the two populations (Supplementary Figs. 2 and 3).
