Chunk #35 — Results — Nondependent drinking and alcohol dependence alter cell death, proliferation, immature neurons, survival and neurogenesis in the hippocampal SGZ
Both nondependent and dependent groups show significant reductions in BrdU cell number (survival, F2,14 = 16.9, p < 0.01, Fig. 4e) compared with naïve control. Alcohol dependence decreased percent of cells that were NeuN positive (neurogenesis, F2,27 72.17, p < 0.01, Fig. 4f) compared with nondependent drinking and control conditions. Mature neurons were calculated by applying the percentage of BrdU cells that colabeled with NeuN to the actual BrdU cell counts. Nondependent drinking animals showed reduced mature neurons compared to naïve controls, and alcohol dependence showed an even greater decrease, significantly different from nondependent and naïve groups (F2,27 = 72.17, p < 0.01, Fig. 4g).
