Among the 10 modules detected, several showed differential expression between those with and without AUD (Fig. 6A, Supplementary Table 14): module 2 genes in astrocytes, module 7 in D1/D2 MSNs (also marginally significant in oligodendrocytes, padj = 0.054), and module 1 in microglia (padj < 0.05). Module 7 target genes were enriched for several pathways from GP Cellular Component database, including collagen-containing extracellular matrix (padj = 0.003), vesicle (padj = 0.007) and basement membrane (padj = 0.007).
