Where individual SNPs were associated with CRP levels, estimated haplotypes were associated with plasma CRP levels in a similar manner. The tagging SNPs for H1 were individually associated with higher CRP levels. Compared to H1, H3 and H4 were associated with 24–44% lower CRP levels among both men and women, and these findings were as expected from their individual variant alleles. For comparison, H1 and H5, which included the triallelic proxy, were both associated with higher CRP levels.
