Five common haplotypes (H1-H5) had an estimated frequency ≥5% ( Table 5 ). H1 with minor alleles of 1919A>T and 3014G>A and major alleles of all others, was the most frequent haplotype and set as the reference haplotype in subsequent analyses. H2, with minor allele of 5237A>G, and H3, with minor allele of 3872C>T, had estimated frequencies ranging from 25–30%. Neither H2 nor H3 was associated with risk of CHD. However, H4, with an estimated frequency of 6–7%, was associated with an increased risk of CHD in both women (RR 1.66, 95% CI 1.02–2.71) and men (RR 1.90, 95% CI 1.25–2.88). The difference between H3 and H4 may be attributable to the minor allele of 2667G>C.
